Prdm16 Amplifies Notch Signaling and Suppresses Venous Lineage Specification to Prevent Arteriovenous Malformations During Vascular Development
Together, our data demonstrate an intricate interplay between Prdm16 and Notch in ECs and indicate that Prdm16 signaling may constitute a novel therapeutic target for arteriovenous malformations.
Authors
- Roxana Ola (ORCID: https://orcid.org/0000-0002-2566-4431)
- Maike Frye (ORCID: https://orcid.org/0000-0002-6257-7636)
- Hannelore Kemps (ORCID: https://orcid.org/0000-0001-9248-1697)
- Manu Beerens (ORCID: https://orcid.org/0000-0002-7398-7761)
- Nicholas D. Leigh (ORCID: https://orcid.org/0000-0002-6978-6254)
- Jore Van Wauwe (ORCID: https://orcid.org/0000-0003-2969-1805)
- Margo Daems (ORCID: https://orcid.org/0000-0002-6961-644X)
- Ashmita KC
- Luttun Aernout
- Chris Finck
- Sander Craps (ORCID: https://orcid.org/0000-0002-8574-7044)
- Lisabel Asuncion
- Thomas Renné
- C A Macrae
- Pavithra Janarthanan
- Daniela Panáková
- Shane Wright
- Christian Müller
Institutions
- Boston University (US)
- Brigham and Women's Hospital (US)
- Royal College of Surgeons in Ireland (IE)
- Universität Hamburg (DE)
- Lund University (SE)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- VIB-KU Leuven Center for Cancer Biology (BE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- University Hospital Schleswig-Holstein (DE)
- German Centre for Cardiovascular Research (DE)
- University Medical Centre Mannheim (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1161/atvbaha.125.323552
- Primary Topic
- Vascular Anomalies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00