The impacts of androgen receptor on treatment response and survival in triple-negative breast cancer treated with neoadjuvant chemotherapy: a single-center retrospective study

Overall, we concluded that AR negativity was linked to increased proliferative activity and complete axillary response in TNBC patients. AR positivity, on the other hand, was associated with residual nodal disease. Ultimately, we could show no significant influence of AR expression on survival. Our findings suggest that AR may serve as a potential biomarker for predicting axillary response in TNBC.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-02-19
DOI
https://doi.org/10.3389/fonc.2026.1756969
Primary Topic
Breast Cancer Treatment Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

The impacts of androgen receptor on treatment response and survival in triple-negative breast cancer treated with neoadjuvant chemotherapy: a single-center retrospective study

Mehmet Furkan Sağdıç, Suat Kutun, Zarife Melda Bulut, Cihangir Özaslan et al.
Frontiers in Oncology
Breast Cancer Treatment Studies
article

The impacts of androgen receptor on treatment response and survival in triple-negative breast cancer treated with neoadjuvant chemotherapy: a single-center retrospective study

Mehmet Furkan Sağdıç, Suat Kutun, Zarife Melda Bulut, Cihangir Özaslan, Seda Karaçam
article en

Abstract

Overall, we concluded that AR negativity was linked to increased proliferative activity and complete axillary response in TNBC patients. AR positivity, on the other hand, was associated with residual nodal disease. Ultimately, we could show no significant influence of AR expression on survival. Our findings suggest that AR may serve as a potential biomarker for predicting axillary response in TNBC.

Frontiers in OncologyVol. 16
Ministry of Health (TR), Gülhane Askerî Tıp Akademisi (TR), Memorial Ankara Hospital (TR), Kharadar General Hospital (PK), Education Training And Research (US)
Good health and well-being
Openalex Percentile: Top 49%
Breast Cancer Treatment Studies
DOIOpen Access PDFOpenAlex
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The impacts of androgen receptor on treatment response and survival in triple-negative breast cancer treated with neoadjuvant chemotherapy: a single-center retrospective study — Mehmet Furkan Sağdıç, Suat Kutun, et al. · Frontiers in Oncology (2026) | TGRS Research Map | TGRS