400 AU/mL IgG protective threshold against SARS-CoV-2 XBB reinfection in Chinese inactivated vaccine recipients: implications for booster vaccination
The 400 AU/mL IgG threshold provides a actionable quantitative guideline for prioritizing booster doses in Chinese adults aged ≥60 years (the fastest antibody decay subgroup) and high-risk groups. Routine antibody testing combined with this threshold could optimize targeted COVID-19 vaccination strategies in inactivated vaccine-predominant populations.
Authors
- Quanjun Fang (ORCID: https://orcid.org/0000-0002-6001-6800)
- Zhiying Yin (ORCID: https://orcid.org/0000-0002-7678-5989)
- Mingzhu Yin (ORCID: https://orcid.org/0000-0002-6964-7131)
- Shuangqing Wang (ORCID: https://orcid.org/0000-0002-3707-5474)
- Fei Zhao (ORCID: https://orcid.org/0000-0003-2878-425X)
- Canya Fu
- Wenjie Xu
- Xiaoying Gong
- Canjie Zheng
Institutions
- Zhejiang Chinese Medical University (CN)
- Taiwan Centers for Disease Control (TW)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-19
- DOI
- https://doi.org/10.3389/fimmu.2026.1768679
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00