Real-World Performance of <i>Aspergillus</i> and Mucorales Polymerase Chain Reaction Assays on Bronchoalveolar Lavage Fluid in Immunocompromised Children and Young Adults
We describe use of Aspergillus and Mucorales polymerase chain reaction (PCRs) in 54 immunocompromised children and young adults undergoing 66 bronchoscopies. Test positivity was 2/54 (3.2%) and 1/59 (1.7%) for Aspergillus and Mucorales. For Aspergillus PCRs, 4/54 (7.4%) positively impacted management, compared to 4/59 (6.8%) for Mucorales. Fungal PCRs may influence care of immunocompromised patients, though overall impact was limited.
Authors
- Daniel Whitehurst (ORCID: https://orcid.org/0000-0002-8248-1738)
- Grant Paulsen (ORCID: https://orcid.org/0000-0002-8901-6513)
- W Otto (ORCID: https://orcid.org/0000-0001-7959-1445)
- Caitlin Brammer
- Lara Danziger-Isakov
- Hilary Miller-Handley
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Journal of the Pediatric Infectious Diseases Society
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1093/jpids/piag012
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00