Alignment of in vitro and in vivo pulmonary inflammation models using crystalline quartz silica
By extending exposure duration and aligning time points, this study identified inflammatory biomarkers that correlate between an in vitro lung model and in vivo data. These findings demonstrate the value of refined in vitro models for assessing particle-induced lung inflammation and support their relevance for hazard assessment.
Authors
- Fabian Blank (ORCID: https://orcid.org/0000-0002-3374-0414)
- Sandeep Keshavan (ORCID: https://orcid.org/0000-0002-2403-4083)
- Isidora Loncarevic (ORCID: https://orcid.org/0000-0001-9056-5870)
- Sandor Balog (ORCID: https://orcid.org/0000-0002-4847-9845)
- Seyran Mutlu (ORCID: https://orcid.org/0009-0008-0289-3881)
- Barbara Rothen‐Rutishauser (ORCID: https://orcid.org/0000-0002-7805-9366)
- Martina Dzepic
- Alke Petri-Fink
Institutions
- University of Bern (CH)
- University of Fribourg (CH)
- University Hospital of Bern (CH)
- Adolphe Merkle Institute (CH)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1186/s12989-026-00665-w
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- University of Bern
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung