Simultaneous electrochemical detection of imipenem and meropenem using a Pt–Au bimetallic nanoparticle–decorated 3D graphene oxide modified glassy carbon electrode

The goal of this study was to create a low-cost, simultaneous, and sensitive electrochemical sensor for detecting the imipenem and meropenem. In order to determine them simultaneously, the first electrochemical sensor was created by combining a glassy carbon electrode (GCE) with a nanocomposite made of platinum-gold bimetallic nanoparticle-decorated three-dimensional graphene oxide (Pt-Au Bm-NPs/3D GO). Electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) were used to evaluate the surface of Pt-Au Bm-NPs/3D GO/GCE. imipenem's electrochemical signals increased as a result of the improvement of many sensitivity-affecting factors, including pH, electrode composition, and scan rate. The analysis of the CV data revealed that imipenem's and meropenem's redox were completely irreversible reactions. Chronoamperometry was utilized to ascertain the imipenem's and meropenem's diffusion coefficients (1.25 ± 0.02 × 10^{- 5} cm²s^{- 1} and 5.24 ± 0.02 × 10^{- 5} cm²s^{- 1}, respectively). The imipenem and meropenem linear dynamic ranges were 0.001-800.0 µM with detection limits of 0.18 nM and 0.14 nM, respectively. Additionally, for the electrochemical oxidation of imipenem and meropenem, the DPV findings revealed two well-resolved anodic waves with a peak separation of around 230 mV, allowing for the simultaneous identification of both chemicals. It is very appropriate for detecting imipenem and meropenem in real samples because to its high sensitivity, low detection limit (nanomolar), remarkable repeatability, and ease of manufacture and renewal of the electrode.