Inhibition of Death-Associated Protein Kinase 1 ameliorates central and peripheral pathological changes in a mouse model of Parkinson’s disease
DAPK1 drives multisystem pathology along the gut-brain axis in PD, where its overexpression promotes α-syn accumulation and intestinal inflammation. Pharmacological DAPK1 inhibition concurrently ameliorates CNS and ENS pathology,establishing it as a promising disease-modifying target for holistic PD intervention.
Authors
- Zhengwei Chen (ORCID: https://orcid.org/0000-0003-3067-0155)
- Yumeng Liu (ORCID: https://orcid.org/0000-0002-5845-1547)
- Wei Han (ORCID: https://orcid.org/0009-0003-1089-5194)
- Zuowei Duan
- Aiping Gong
- Zhining Li
Institutions
- Xuzhou Medical College (CN)
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Second Affiliated Hospital of Xuzhou Medical College (CN)
Publication Details
- Journal
- Neuroscience Letters
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1016/j.neulet.2026.138546
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00