Lactylation in colorectal cancer: Unveiling novel mechanisms in metabolism, progression and therapeutic targeting
Lactylation serves as a fundamental metabolic‒epigenetic link driving aggressive phenotypes in colorectal cancer. By delineating these tissue-specific mechanisms and proposing next-generation site-specific targeting strategies, this review provides a theoretical foundation for developing precision medicine interventions to overcome therapy resistance in colorectal cancer patients.
Authors
- Tao Gui (ORCID: https://orcid.org/0000-0003-4764-4834)
- Ming Liu (ORCID: https://orcid.org/0000-0001-9240-2119)
- Yi Ji (ORCID: https://orcid.org/0000-0002-4040-8807)
- Guoli Wei (ORCID: https://orcid.org/0000-0001-6028-1586)
- Jiege Huo (ORCID: https://orcid.org/0000-0002-7170-6225)
- Weiwei Li
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Traditional Chinese Medicine Hospital (CN)
- Jiangsu Provincial Academy of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/ctm2.70629
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province