Clinical Determinants of Early Achievement of the Therapeutic Teicoplanin Trough Concentration Range in Adult Cancer Patients
The fixed high-dose loading regimen of teicoplanin evaluated in this study achieves a day 4 trough concentration of 20 to 30 mg/L in about half of adult cancer patients. Higher body weight, febrile neutropenia, and lower serum albumin may help identify patients who require intensified loading and early therapeutic drug monitoring.
Authors
- Toshihisa Nakashima (ORCID: https://orcid.org/0000-0002-6048-2502)
- Osamu Kobayashi (ORCID: https://orcid.org/0000-0001-7517-5495)
- Mika Shiotsuka (ORCID: https://orcid.org/0000-0003-1219-8387)
- Keiji Okinaka
- Hironobu Hashimoto (ORCID: https://orcid.org/0000-0002-5907-5547)
Institutions
- National Cancer Centre Japan (JP)
- Prevention Group (US)
- Tokyo National Hospital (JP)
Publication Details
- Journal
- Annals of Pharmacotherapy
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1177/10600280261421670
- Primary Topic
- Neutropenia and Cancer Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00