Disruption of proteoglycan 4 (PRG4)-CD44 signaling modulates chronic synovitis in conditionally inactivated mice
CD44 loss abrogated chronic synovitis observed following PRG4 loss. Dysfunction in PRG4 signaling, demonstrated by lower tissue levels of PRG4 along with higher CD44, XO and HIF-1α, was associated with high-grade synovitis. Targeting the downstream events of PRG4 loss is potentially therapeutic in OA synovitis.
Authors
- Thomas Zhao
- L. Zhang
- Gregory D. Jay (ORCID: https://orcid.org/0000-0003-1517-8488)
- Khaled A. Elsaid (ORCID: https://orcid.org/0000-0002-8925-4255)
- Ava Marks
- Derek Jenkins
Institutions
- Chapman University (US)
- Providence College (US)
- Brown University (US)
- Rhode Island Hospital (US)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1186/s13075-026-03773-2
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00