Monogenic forms of inflammatory bowel disease: Genetic mechanisms, models, and clinical implications

This review focuses on the genetic bases of IBD, with a particular emphasis on its monogenic forms, and highlights the role of in vitro and in vivo models in unraveling IBD pathogenesis and advancing treatment modalities.

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Publication Details

Journal
Molecular Medicine
Published
2026-02-19
DOI
https://doi.org/10.1186/s10020-026-01424-5
Primary Topic
Inflammatory Bowel Disease
Type
article
Field-Weighted Citation Impact
0.00

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article

Monogenic forms of inflammatory bowel disease: Genetic mechanisms, models, and clinical implications

Shabnam Shahrokh, Georges Dimitrov, S. I. Dimitrov, Pejman Rohani et al.
Molecular Medicine
Inflammatory Bowel Disease
article

Monogenic forms of inflammatory bowel disease: Genetic mechanisms, models, and clinical implications

Shabnam Shahrokh, Georges Dimitrov, S. I. Dimitrov, Pejman Rohani, Amirhossein Ghorbanpour, Mehdi Totonchi
article en

Abstract

This review focuses on the genetic bases of IBD, with a particular emphasis on its monogenic forms, and highlights the role of in vitro and in vivo models in unraveling IBD pathogenesis and advancing treatment modalities.

Molecular MedicineVol. 32(1)
Centre National de la Recherche Scientifique (FR), Inserm (FR), Royan Institute (IR), University of Tehran (IR), Institute of Molecular Biology (BG), Research Institute for Endocrine Sciences (IR), Children's Medical Center (IR), Centre hospitalier universitaire d'Orléans (FR), Shahid Beheshti University of Medical Sciences (IR), Université Grenoble Alpes (FR)
HORIZON EUROPE Framework Programme
Good health and well-being
Openalex Percentile: Top 48%
Inflammatory Bowel Disease
DOIOpen Access PDFOpenAlex
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Monogenic forms of inflammatory bowel disease: Genetic mechanisms, models, and clinical implications — Shabnam Shahrokh, Georges Dimitrov, et al. · Molecular Medicine (2026) | TGRS Research Map | TGRS