Preconception Hydroxychloroquine Therapy Restores Placental Function and Improves Pregnancy Outcomes in Obstetric Antiphospholipid Syndrome

We redefine HCQ as a proactive placental resetter that neutralizes oxidative stress barriers preconception, thereby liberating trophoblast differentiation capacity. This work positions HCQ-pre as the critical intervention phase-a paradigm shift from reactive adjunct to preemptive root-cause interception, providing the mechanistic foundation for optimizing OAPS management through timely individualized prophylaxis. <i>Antioxid. Redox Signal.</i> 00, 000-000.