A Reproducible Ceramide Phenotype of Sepsis Across Aetiologies – A Monocenter Cohort Study
Sepsis is characterised by a reproducible ceramide signature that does not differ by SARS-CoV-2 status. These data argue against non-selective acid sphingomyelinase inhibition and instead support evaluation of selective ceramide synthase targeting as a therapeutic approach in sepsis.
Authors
- Stephan A. Schmid (ORCID: https://orcid.org/0000-0003-2222-2926)
- G Liebisch
- Sabrina Krautbauer
- Marcus Höring
- P Mester
- Christa Buechler
- Vlad Pavel
- Martina Müller
Institutions
- University Hospital Regensburg (DE)
- University of Regensburg (DE)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/jir.s571836
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitätsklinikum Regensburg
- Universität Regensburg