Novel derivatives of tetrahydrocarbazole as NADPH oxidase 2 and 4 inhibitors: <i>in silico</i> , synthesis, and <i>in vitro</i> evaluation

Tetrahydrocarbazole-6-sulfonamides represent a versatile scaffold for selective inhibition of NOX2 and NOX4, with ASP5 and ASP20 identified as promising leads for targeting NOX-mediated oxidative stress in TBI.

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Publication Details

Journal
Future Medicinal Chemistry
Published
2026-02-19
DOI
https://doi.org/10.1080/17568919.2026.2628561
Primary Topic
Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Type
article
Field-Weighted Citation Impact
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article

Novel derivatives of tetrahydrocarbazole as NADPH oxidase 2 and 4 inhibitors: in silico , synthesis, and in vitro evaluation

Dimple Chopra, Akashdeep Singh Pathania, Dhandeep Singh, Kavita Badhai et al.
Future Medicinal Chemistry
Neutrophil, Myeloperoxidase and Oxidative Mechanisms
article

Novel derivatives of tetrahydrocarbazole as NADPH oxidase 2 and 4 inhibitors: in silico , synthesis, and in vitro evaluation

Dimple Chopra, Akashdeep Singh Pathania, Dhandeep Singh, Kavita Badhai, Nirmal Singh
article en

Abstract

Tetrahydrocarbazole-6-sulfonamides represent a versatile scaffold for selective inhibition of NOX2 and NOX4, with ASP5 and ASP20 identified as promising leads for targeting NOX-mediated oxidative stress in TBI.

Future Medicinal Chemistry
Punjabi University (IN)
Clean water and sanitation
Openalex Percentile: Top 49%
Neutrophil, Myeloperoxidase and Oxidative Mechanisms
DOISourceOpenAlex
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Novel derivatives of tetrahydrocarbazole as NADPH oxidase 2 and 4 inhibitors: <i>in silico</i> , synthesis, and <i>in vitro</i> evaluation — Dimple Chopra, Akashdeep Singh Pathania, et al. · Future Medicinal Chemistry (2026) | TGRS Research Map | TGRS