Synergistic inhibition of Streptococcus mutans biofilms by fluoride and epigallocatechin gallate: insights from multi-omics analysis
NaF and EGCG synergistically disrupt <i>S. mutans</i> biofilms by simultaneously impairing extracellular polysaccharide synthesis, redox balance, and central metabolic activity. These findings support the potential of combining EGCG with fluoride to enhance caries prevention strategies.
Authors
- Junjun Zhao
- Tiantian Wu
- Long Jiang
Institutions
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-02-19
- DOI
- https://doi.org/10.3389/fmicb.2026.1766833
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University