Targeting STING Signalling Polarizes Tumor-Associated Neutrophils to Boost Anticancer and Abscopal Antimetastatic Functions
Targeting STING provides polarization of TANs phenotype toward anticancer N1 subtype. Obtained data fills the gaps in the knowledge of the impact of STING-activating therapy on TANs functions, participation in the metastasis process, and acquisition of M1 phenotype by macrophages.
Authors
- Ewelina Pilny (ORCID: https://orcid.org/0000-0003-1483-4543)
- Alina Drzyzga (ORCID: https://orcid.org/0000-0001-5742-0821)
- Ryszard Smolarczyk (ORCID: https://orcid.org/0000-0002-1131-289X)
- Justyna Czapla
- Sybilla Matuszczak (ORCID: https://orcid.org/0000-0001-6359-2582)
- Joanna Ciepła
- Magdalena Jarosz-Biej
- Tomasz Cichoń
Institutions
- National Institute of Oncology (HU)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
Publication Details
- Journal
- ImmunoTargets and Therapy
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/itt.s576457
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00