Critique on the Generalizability of a Proposed Clinical Management Algorithm for Atypia of Undetermined Significance ( <scp>AUS</scp> ) in the Absence of Molecular Testing in Thyroidology

This Letter to the Editor critically appraises a recent proposal for managing Atypia of Undetermined Significance (AUS) in thyroid fine‐needle aspiration cytology without molecular testing. The authors argue that the algorithm's success is intrinsically linked to the specialised, high‐volume center where the data originated, limiting its broad applicability due to variations in AUS rates, risk of malignancy, and regional clinical practices.

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Publication Details

Journal
Cytopathology
Published
2026-02-18
DOI
https://doi.org/10.1111/cyt.70064
Primary Topic
Thyroid Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Critique on the Generalizability of a Proposed Clinical Management Algorithm for Atypia of Undetermined Significance ( AUS ) in the Absence of Molecular Testing in Thyroidology

Demet Kaya Şengül, Ilker Sengul
Cytopathology
Thyroid Cancer Diagnosis and Treatment
article

Critique on the Generalizability of a Proposed Clinical Management Algorithm for Atypia of Undetermined Significance ( AUS ) in the Absence of Molecular Testing in Thyroidology

Demet Kaya Şengül, Ilker Sengul
article en

Abstract

This Letter to the Editor critically appraises a recent proposal for managing Atypia of Undetermined Significance (AUS) in thyroid fine‐needle aspiration cytology without molecular testing. The authors argue that the algorithm's success is intrinsically linked to the specialised, high‐volume center where the data originated, limiting its broad applicability due to variations in AUS rates, risk of malignancy, and regional clinical practices.

Cytopathology
Giresun University (TR)
Openalex Percentile: Top 53%
Thyroid Cancer Diagnosis and Treatment
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