Eliglustat prevents acute kidney injury caused by Shiga toxin 2 in lethal and sublethal rat models of hemolytic uremic syndrome
The oral treatment with EG could be a therapeutic strategy to prevent the action of Stx2 and the development of acute kidney injury in diarrhea-associated HUS patients.
Authors
- Daiana S. Sánchez
- Elsa Zotta (ORCID: https://orcid.org/0000-0002-8763-5046)
- Lilian K. Fischer Sigel
- Claudia Silberstein
Institutions
- Universidad de Ciencias Medicas (CR)
- Universidad de Buenos Aires (AR)
- Agricultural Plant Physiology and Ecology Research Institute (AR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-19
- DOI
- https://doi.org/10.3389/fphar.2026.1736204
- Primary Topic
- Escherichia coli research studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Universidad de Buenos Aires
- CYTED Ciencia y Tecnología para el Desarrollo
- Secretaría de Ciencia y Técnica, Universidad de Buenos Aires