Systemic cachexia and muscle–bone crosstalk drive depression-related joint remodeling and pain
Depression-related joint pain is not merely a psychological phenomenon but a complex organic disorder with defined structural and molecular underpinnings. It involves dysregulated lipid metabolism, aging-associated pathways, and multi-organ interactions between fat, muscle, bone, and the nervous system.
Authors
- Chen Zhao (ORCID: https://orcid.org/0000-0003-1361-8419)
- Pengcheng Liu (ORCID: https://orcid.org/0000-0002-9144-1623)
- George Zhang (ORCID: https://orcid.org/0000-0003-2073-7109)
- Weiqi Li
- Jialong Wu
- Ran Duan
Institutions
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan University (CN)
- Shanghai Stomatological Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1097/js9.0000000000004653
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00