Anjiang formula inhibits PVN microglial activation and lowers blood pressure by targeting RhoA/ROCK2 pathway: a retrospective clinical and experimental study
AJ provides antihypertensive efficacy in elderly patients. These benefits are mechanistically driven by Shinflavanone-mediated inhibition of ROCK2, which attenuates central neuroinflammation and restores redox homeostasis in the PVN.
Authors
- Lianfa Chen
- Aling Shen
- Dawei Lian
- Jing Wang
- Jun Chen
- Jin Luo
- Meizu Wu
- Xuanjing Chen
- Zhenglin Chen
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Xiangyang Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-19
- DOI
- https://doi.org/10.3389/fphar.2026.1795297
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Fujian Province