A simple and highly sensitive LC-MS/MS bioanalytical method for phosphorodiamidate morpholino oligonucleotides in plasma
A simple and highly sensitive bioanalytical method for the determination of viltolarsen was established by optimizing RPLC and PPT, and the method was successfully applied to a phosphorodiamidate morpholino oligomers with a different sequence.
Authors
- Kazutomi Kusano
- Shunji Imai (ORCID: https://orcid.org/0009-0005-2906-4117)
- Rei Mitamura
- Tetsuhiro Yamada
- Tsubasa Kameyama
- Makoto Niwa (ORCID: https://orcid.org/0000-0002-2355-1222)
Institutions
- Nippon Shinyaku (Japan) (JP)
Publication Details
- Journal
- Bioanalysis
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1080/17576180.2026.2632688
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00