Mavacamten optimizes myocardial work in patients with obstructive hypertrophic cardiomyopathy: a non-invasive pressure–strain analysis
Myocardial work indices derived from non-invasive pressure-strain analysis were feasible to obtain in patients with oHCM in this study. Mavacamten therapy decreases workload index, constructive and wasted work, and synchronizes myocardial contractility, reflecting normalization of myocardial energetics. These findings reinforce the role of Mavacamten as a targeted therapy in oHCM.
Authors
- Kawa Mohemed
- J.-C. Reil
- M. Wiemer
- Cédric Coppée
- Max (Dr. med.) Potratz
- V. Sequeira
- S. Scholtz
- C. Maack
- V. Rudolph
- F. Langkamp
Institutions
- Heart and Diabetes Center North Rhine-Westphalia (DE)
Publication Details
- Journal
- Clinical Research in Cardiology
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1007/s00392-026-02855-0
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00