Skeletal stem cell lineages in osteosarcoma and bone metastasis
Collectively, these findings highlight Fgfr3<sup>+</sup> endosteal stem cells as candidate cells of origin for osteosarcoma and underscore the dual role of SSC-derived lineages in both tumor initiation and progression. Targeting SSC-derived endosteal niches may provide new therapeutic opportunities for bone malignancies.
Authors
- Yuki Matsushita (ORCID: https://orcid.org/0000-0001-9577-3249)
- Keita Kondo
Institutions
- University of Nagasaki (JP)
- Nagasaki University (JP)
Publication Details
- Journal
- Journal of Bone and Mineral Metabolism
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1007/s00774-026-01700-8
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00