Effect of exercise modality and intensity on endothelial function in patients with cardiovascular disease: a systematic review and network meta-analysis
Exercise significantly enhances endothelial function in in patients with CVD. HIIE emerged as the most robust and evidence-based modality, demonstrating superior efficacy over moderate continuous exercise. While high-intensity combined protocols (HCE) show significant theoretical potential, randomised trials are urgently needed to confirm their efficacy. Current evidence supports HIIE as a primary strategy for vascular adaptation in cardiac rehabilitation.
Authors
- Laura Fuertes-Kenneally (ORCID: https://orcid.org/0000-0003-1361-8806)
- Noemí Sempere-Ruiz (ORCID: https://orcid.org/0000-0002-1271-7194)
- Sabina Baladzhaeva (ORCID: https://orcid.org/0009-0009-8730-5600)
- Agustín Manresa‐Rocamora (ORCID: https://orcid.org/0000-0002-1399-2411)
- Ana Sanz-Rocher (ORCID: https://orcid.org/0009-0007-1476-9776)
- José Manuel Sarabia
- Carles Blasco-Peris
Institutions
- Universitat de Miguel Hernández d'Elx (ES)
- University of Alicante (ES)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
Publication Details
- Journal
- European Journal of Preventive Cardiology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1093/eurjpc/zwag118
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 0.00