The Cases of Acute Necrotizing Encephalopathy Due to Human Herpes Virus-6

These cases highlight the potential for HHV-6 to cause severe encephalopathy in immunocompetent children. Early recognition, neuroimaging, and cerebrospinal fluid polymerase chain reaction testing are essential for diagnosis. Combined antiviral and immunomodulatory therapies may improve outcomes by addressing both viral replication and neuroinflammation.

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Publication Details

Journal
The Pediatric Infectious Disease Journal
Published
2026-02-19
DOI
https://doi.org/10.1097/inf.0000000000005187
Primary Topic
Infectious Encephalopathies and Encephalitis
Type
article
Field-Weighted Citation Impact
0.00
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article

The Cases of Acute Necrotizing Encephalopathy Due to Human Herpes Virus-6

Merve Havan, Fatma Pinar Tabanli, İzel YILMAZ, Belkis Hatice Inceli et al.
The Pediatric Infectious Disease Journal
Infectious Encephalopathies and Encephalitis
article

The Cases of Acute Necrotizing Encephalopathy Due to Human Herpes Virus-6

Merve Havan, Fatma Pinar Tabanli, İzel YILMAZ, Belkis Hatice Inceli, Ayşen Durak Aslan, Eda Eyduran, Miraç Yildirim, Halil Özdemir
article en

Abstract

These cases highlight the potential for HHV-6 to cause severe encephalopathy in immunocompetent children. Early recognition, neuroimaging, and cerebrospinal fluid polymerase chain reaction testing are essential for diagnosis. Combined antiviral and immunomodulatory therapies may improve outcomes by addressing both viral replication and neuroinflammation.

The Pediatric Infectious Disease Journal
Ankara University (TR)
Good health and well-being
Openalex Percentile: Top 50%
Infectious Encephalopathies and Encephalitis
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