Co-delivery of endometrial mesenchymal stem cells and macrophages with an electrospun patch suppresses endometrial fibrosis via IL-10 related signaling

Co-delivery system reduced fibrosis and supported an M1-type to M2-type overall change of the mø phenotypes in the endometrial tissue damage model. IL-10 was one of the important factors in inhibiting endometrial fibrosis in the co-delivery system. This study provided significant insights into using a co-delivery system PCL-HA/H-E/mø, to effectively alleviate endometrial fibrosis and potentially for a more effective treatment of IUA.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-02-19
DOI
https://doi.org/10.3389/fimmu.2026.1750456
Primary Topic
Gynecological conditions and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Co-delivery of endometrial mesenchymal stem cells and macrophages with an electrospun patch suppresses endometrial fibrosis via IL-10 related signaling

WenShuang Wang, Y Q Chen, T.K.F. MA, Xiaoqing Zhang et al.
Frontiers in Immunology
Gynecological conditions and treatments
article

Co-delivery of endometrial mesenchymal stem cells and macrophages with an electrospun patch suppresses endometrial fibrosis via IL-10 related signaling

WenShuang Wang, Y Q Chen, T.K.F. MA, Xiaoqing Zhang, Shuhong Li, Jiangru An, Peng Ma, J. Paul Santerre
article en

Abstract

Co-delivery system reduced fibrosis and supported an M1-type to M2-type overall change of the mø phenotypes in the endometrial tissue damage model. IL-10 was one of the important factors in inhibiting endometrial fibrosis in the co-delivery system. This study provided significant insights into using a co-delivery system PCL-HA/H-E/mø, to effectively alleviate endometrial fibrosis and potentially for a more effective treatment of IUA.

Frontiers in ImmunologyVol. 17
University of Toronto (CA), Yuhuangding Hospital (CN), Tissue Regeneration Systems (United States) (US), University of Hong Kong (HK)
Openalex Percentile: Top 48%
Gynecological conditions and treatments
DOIOpen Access PDFOpenAlex
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Co-delivery of endometrial mesenchymal stem cells and macrophages with an electrospun patch suppresses endometrial fibrosis via IL-10 related signaling — WenShuang Wang, Y Q Chen, et al. · Frontiers in Immunology (2026) | TGRS Research Map | TGRS