A Double-blind Randomized Trial of Oral Chlorhexidine Gluconate for Treatment of Oral <i>Staphylococcus aureus</i> Colonization in Healthy Children

We found that a 7-day 0.12% chlorhexidine gluconate mouthwash regimen significantly reduced <i>S. aureus</i> oropharyngeal colonization compared with placebo. This difference persisted at day 29, suggesting that CHG mouthwash may be a promising adjunctive decolonization agent that may decrease the high SSTI recurrence risk in children.

Authors

Institutions

Publication Details

Journal
Open Forum Infectious Diseases
Published
2026-02-15
DOI
https://doi.org/10.1093/ofid/ofag072
Primary Topic
Antimicrobial Resistance in Staphylococcus
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

A Double-blind Randomized Trial of Oral Chlorhexidine Gluconate for Treatment of Oral Staphylococcus aureus Colonization in Healthy Children

Evelyn A Flores, Bryn Launer, Michael Bolaris, Tae Soon Kim et al.
Open Forum Infectious Diseases
Antimicrobial Resistance in Staphylococcus
article

A Double-blind Randomized Trial of Oral Chlorhexidine Gluconate for Treatment of Oral Staphylococcus aureus Colonization in Healthy Children

Evelyn A Flores, Bryn Launer, Michael Bolaris, Tae Soon Kim, Kelly D Young, Greg Tchakalian, Barry Kreiswirth, Lucia Liu, Loren G Miller
article en

Abstract

We found that a 7-day 0.12% chlorhexidine gluconate mouthwash regimen significantly reduced <i>S. aureus</i> oropharyngeal colonization compared with placebo. This difference persisted at day 29, suggesting that CHG mouthwash may be a promising adjunctive decolonization agent that may decrease the high SSTI recurrence risk in children.

Open Forum Infectious DiseasesVol. 13(3)
University of Southern California (US), University of California, Los Angeles (US), Duke University (US), UCLA Medical Center (US), Rancho Los Amigos National Rehabilitation Center (US), Center for Discovery (US), Harbor–UCLA Medical Center (US), Vanderbilt University Medical Center (US)
Openalex Percentile: Top 50%
Antimicrobial Resistance in Staphylococcus
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.