Sex, social rank, and nicotine co-administration shape cocaine- and cocaethylene-induced reinstatement in monkeys

Thus, social rank impacts cocaine- and cocaethylene-induced reinstatement, and the effects of nicotine were influenced by sex. This underscores the value of translational models that move beyond single-drug approaches and suggest that especially in women with CUD, abstaining from nicotine would increase the likelihood of remaining abstinent from cocaine.