Preoperative Circulating Tumor DNA Detection and Risk Stratification in Esophageal Squamous Cell Carcinoma
Preoperative ctDNA detection was significantly associated with occult nodal metastasis and recurrence risk in clinical N0 early-stage ESCC in this study. Among patients with T2N0 ESCC, ctDNA may serve as a complementary biomarker to inform neoadjuvant treatment escalation and support more personalized therapeutic strategies.
Authors
- Hwang-Phil Kim
- D. J. Kim
- Jun-Gi Jeong
- Tae Hee Hong (ORCID: https://orcid.org/0000-0003-2708-8893)
- Ha Eun Kim (ORCID: https://orcid.org/0000-0002-7297-2832)
- Jin Gu Lee
- Se-Hoon Lee
- Jong Ho Cho
- Byung Jo Park
- Young Ho Yang
- Seong Yong Park
- Dongsoo Kyung
- Junghee Lee
- Hong Kwan Kim
- Young Mog Shim
- Yong Soo Choi
- Jingjun Zhu
- Chang Young Lee
- Yeong Jeong Jeon
Institutions
- Nexen (Canada) (CA)
- Samsung (South Korea) (KR)
- Severance Hospital (KR)
- Samsung Medical Center (KR)
- Gangnam Severance Hospital (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- JAMA Surgery
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1001/jamasurg.2025.6755
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00