Assessing the fragility index of randomized controlled trials on carotid artery stenosis: a systematic review

A small number of events is required to change the findings of RCTs comparing CEA to CAS from statistically significant to statistically nonsignificant. All studies that reported LTFU had LTFU greater than its FI, calling into question the robustness of these results.

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Publication Details

Journal
Canadian Journal of Surgery
Published
2026-02-18
DOI
https://doi.org/10.1503/cjs.008525
Primary Topic
Cerebrovascular and Carotid Artery Diseases
Type
article
Field-Weighted Citation Impact
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article

Assessing the fragility index of randomized controlled trials on carotid artery stenosis: a systematic review

Braeden D. Newton, Eva Liu, Amy Zhou, Lissa Ogieglo et al.
Canadian Journal of Surgery
Cerebrovascular and Carotid Artery Diseases
article

Assessing the fragility index of randomized controlled trials on carotid artery stenosis: a systematic review

Braeden D. Newton, Eva Liu, Amy Zhou, Lissa Ogieglo, N Tilbury, Uzair Ahmed, Michael Kelly, Hsuan Ming Su, Amit Persad
article en

Abstract

A small number of events is required to change the findings of RCTs comparing CEA to CAS from statistically significant to statistically nonsignificant. All studies that reported LTFU had LTFU greater than its FI, calling into question the robustness of these results.

Canadian Journal of SurgeryVol. 69(1)
University of Saskatchewan (CA)
Good health and well-being
Openalex Percentile: Top 50%
Cerebrovascular and Carotid Artery Diseases
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