Unravelling Voriconazole's Hepatic Metabolism: A Narrative Review on Factors Impacting Voriconazole‐N‐Oxide Exposure
VRC dose, CRP, age and CYP2C19 genotype are the primary covariates affecting NOX or MR, and renal and liver function should also be considered in future population pharmacokinetic models and TDM protocols.
Authors
- Matthias Gijsen (ORCID: https://orcid.org/0000-0003-1378-3772)
- Florian Lemaitre
- Christelle Boglione‐Kerrien (ORCID: https://orcid.org/0000-0002-4527-0958)
- Pieter Annaert (ORCID: https://orcid.org/0000-0003-3525-7351)
- Veerle Grootaert
- Isabel Spriet (ORCID: https://orcid.org/0000-0001-6342-0676)
- Katelijne Floré
- Katrien Lagrou
- Janne Hubrechts
- Beatrijs Mertens
Institutions
- Inserm (FR)
- Institut de Recherche en Santé, Environnement et Travail (FR)
- CIC Rennes (FR)
- AZ Sint-Jan (BE)
- AZ Turnhout (BE)
- Centre Hospitalier Universitaire de Rennes (FR)
- Université de Rennes (FR)
- KU Leuven (BE)
Publication Details
- Journal
- Mycoses
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1111/myc.70158
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00