Modulation of neurofluid fluctuation frequency by baseline carbon dioxide in awake humans: the role of the autonomic nervous system
These results suggest that both hyper- and hypocapnia disrupt how CSF responds to autonomic regulation, seen in deviations from normal cardiac and respiratory responses. Our work reveals neurofluid dynamics' sensitivity to CO<sub>2</sub>'s frequency response, best explained by autonomic modulation. Modulating basal CO<sub>2</sub> offers a new way to influence human neurofluid dynamics, independent of sleep or neuronal activity.
Authors
- Xiaole Zhong (ORCID: https://orcid.org/0000-0002-8641-5658)
- Catie Chang
- J. Jean Chen
Institutions
- University of Toronto (CA)
- Vanderbilt University (US)
- Baycrest Hospital (CA)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fphys.2026.1750101
- Primary Topic
- Neuroscience of respiration and sleep
- Type
- article
- Field-Weighted Citation Impact
- 0.00