Freiburg Neuropathology Case Conference: A 2-Year-Old Child with Progressive Headache, Nausea, and Personality Change

A 2-year-old child presented with progressive headache, nausea, and personality changes which triggered cranial magnetic resonance maging (MRI) and revealed a large right parietal mass lesion.Given the size and mass effect, urgent surgical resection was indicated.The patient was positioned supine with the head turned to the left.A parietal craniotomy including the central region was performed, and the dura was opened toward the sinus.A superficially well-demarcated mass was encountered, markedly compressing the underlying brain.Frozen section analysis was consistent with a malignant small-cell tumour,