Multi-level evidence reveals KCTD15 and FAM19A2 as key targets in PFOA/PFOS-mediated PCOS pathogenesis

This study identifies KCTD15/FAM19A2 as potential hub genes linked to PFOA/PFOS exposure in PCOS, providing preliminary evidence for a causal association. These findings may inform future research into targeted interventions within environmental reproductive toxicology.

Authors

Shanshan Zhang
Mingming Wang
Liying Ge
Yuxiao Jiang

Institutions

Xuzhou Medical College (CN)
Jining Medical University (CN)

Publication Details

Journal: Ecotoxicology and Environmental Safety
Published: 2026-02-01
DOI: https://doi.org/10.1016/j.ecoenv.2026.119900
Primary Topic: Per- and polyfluoroalkyl substances research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Multi-level evidence reveals KCTD15 and FAM19A2 as key targets in PFOA/PFOS-mediated PCOS pathogenesis

Shanshan Zhang, Mingming Wang, Liying Ge, Yuxiao Jiang

Feb 1, 2026

Ecotoxicology and Environmental Safety

Per- and polyfluoroalkyl substances research

article

Multi-level evidence reveals KCTD15 and FAM19A2 as key targets in PFOA/PFOS-mediated PCOS pathogenesis

Shanshan Zhang, Mingming Wang, Liying Ge, Yuxiao Jiang

February 1, 2026article en

Abstract

Ecotoxicology and Environmental SafetyVol. 311

Xuzhou Medical College (CN), Jining Medical University (CN)

Zero hunger

Openalex Percentile: Top 56%

Per- and polyfluoroalkyl substances research

DOI Open Access PDF OpenAlex

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