Hypertension and Diabetes Cooperatively Drive HSP90 Activation, HSP70 Suppression, and Left Ventricular Interstitial Expansion: Relevance to Maladaptive Myocardial Remodeling
Comorbid AH and DM provoke synergistic HSP90 upregulation, while HSP70 expression is markedly suppressed, indicating a shift from an adaptive to a maladaptive cellular-stress response. The imbalance between HSP90 and HSP70 may represent a key molecular mechanism underlying accelerated structural and functional deterioration of the myocardium in cardiometabolic comorbidity.
Authors
- A. P. Sklifasovskaya (ORCID: https://orcid.org/0000-0002-0042-6015)
- V. A. Goryachev (ORCID: https://orcid.org/0000-0002-2787-5494)
- М. Л. Благонравов (ORCID: https://orcid.org/0000-0001-7838-0486)
- Azova Mm
- Sergey Kurevlev (ORCID: https://orcid.org/0009-0001-6522-1598)
- S. P. Syatkin
- Tatyana Yu. Zotova
- Daniil Yu. Prokofiev
Institutions
- Peoples' Friendship University of Russia (RU)
- Moscow Clinical Scientific Center (RU)
- Botkin Hospital (RU)
Publication Details
- Journal
- Pathophysiology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3390/pathophysiology33010019
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- RUDN University