The Impact of Brain Morphometry on Low Back Pain Risk: A Mendelian Randomization Study
Genetically reduced global cortical surface area and frontal-thalamic brain volumes were causally associated with an increased risk of LBP, providing novel evidence for a central neuroanatomical contribution to pain vulnerability.
Authors
- Ziqun Liu
- Hong Ma (ORCID: https://orcid.org/0000-0002-6260-7954)
- Zhiming Tu (ORCID: https://orcid.org/0000-0001-6508-3247)
- Yanfa Dai (ORCID: https://orcid.org/0000-0003-3846-1673)
- B Jiang (ORCID: https://orcid.org/0009-0002-2045-6307)
- Yawei Li
- Bing Wang
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Department of Science and Technology of Hunan Province (CN)
Publication Details
- Journal
- Journal of Pain Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/jpr.s565590
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00