Electrospun polylactic acid-curcumin-graphene oxide composite nanofibers for wound dressing

In the present study, polylactic acid (PLA)-curcumin (Cur)-graphene oxide (GO) wound dressings were fabricated by the electrospinning method. According to the results, the average diameters of PLA, PLA/Cur, PLA/Cur-0.6GO, and PLA/Cur-1GO and PLA/Cur-1.6GO composite nanofibers were about 266.5 ± 55.1, 375.3 ± 62.6, 393.6 ± 47.8, 449.7 ± 45.3, and 482.8 ± 61.9 nm, respectively. Fourier transform infrared analysis showed that all the mentioned compounds were present in the nanofiber scaffolds. Evaluation of the water absorption of wound dressings within 24 h was estimated at 71%, 162%, 140%, 123%, and 105% for PLA, PLA/Cur, PLA/Cur-0.6GO, and PLA/Cur-1GO and PLA/Cur-1.6GO, respectively. The addition of GO has increased the drug release rate so that the PLA/Cur-1.6GO nanofiber scaffold has the highest release rate. Electrospun composite nanofibers have no toxicity and have a high percentage of cell viability. The adhesion of the grown cells to the nanofibers has increased with the addition of GO. As expected, GO had a significant effect on increasing the mechanical properties of the nanofiber scaffolds. Considering that GO enhanced several desirable properties of the PLA/Cur-GO composite nanofibers, further in vivo investigation is recommended.