Refined in vivo model for bone regeneration: insights into scaffold architecture and porosity
This integrative <i>in vivo</i> model provides a robust workflow for correlating structural, cellular, and molecular dimensions of bone regeneration within the same specimen. The findings show that scaffold macroarchitecture influences both the extent and timing of immune and osteogenic processes. While scaffolds with 250 μm and 500 µm pores supported regeneration, the finer design consistently promoted more advanced tissue formation and maturation. These results underscore the key role of scaffold design in modulating bone healing and highlight this model as a platform for studying structure-function relationships in bone tissue engineering.
Authors
- Olivier Preynat‐Seauve (ORCID: https://orcid.org/0000-0001-5364-967X)
- Daniel Manoil (ORCID: https://orcid.org/0000-0002-9220-3977)
- Nicolò Costantino Brembilla (ORCID: https://orcid.org/0000-0003-1591-1790)
- Baptiste Charbonnier (ORCID: https://orcid.org/0000-0003-2459-9794)
- Stéphane Durual (ORCID: https://orcid.org/0000-0002-9772-8406)
- Fabrice Marger
- Mélanie Freudenreich
- Moustapha Mekki
- Laurine Marger
- Sanae El Harane
- Jérôme Charmet
Institutions
- University of Geneva (CH)
- Inserm (FR)
- HES-SO University of Applied Sciences and Arts Western Switzerland (CH)
- University of Dental Medicine (MM)
- University Hospital of Geneva (CH)
- HES-SO Arc (CH)
- Geneva College (US)
- Nantes Université (FR)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fbioe.2026.1725958
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00