Clathriamine A, an Antibacterial Dimeric Araiosamine Homologue from a Marine Sponge <i>Clathria (Thalysias)</i> sp.
A novel bis-indole, bis-guanidinium alkaloid, clathriamine A (<b>1</b>), has been isolated from a Western Australian marine sponge, <i>Clathria (Thalysias)</i> sp. (order: Poecilosclerida, family: Microcionidae). The structure of <b>1</b> was elucidated via comprehensive NMR analyses as well as TD-DFT predictions of ECD spectra. Biological evaluation against a panel of microorganisms and cell lines revealed potent and selective antibacterial activity for compound <b>1</b>.
Authors
- Gavin R. Flematti (ORCID: https://orcid.org/0000-0003-2545-6939)
- Samuele Sala (ORCID: https://orcid.org/0000-0003-2971-646X)
- Oliver Gomez (ORCID: https://orcid.org/0000-0002-9106-6261)
- Lacey Ernest
- Daniel Vuong (ORCID: https://orcid.org/0000-0002-2451-3148)
- Gareth L. Nealon (ORCID: https://orcid.org/0000-0001-7037-7135)
- Jane Fromont (ORCID: https://orcid.org/0000-0002-8887-4452)
- Brodie W. Bulcock (ORCID: https://orcid.org/0000-0001-9260-4650)
Institutions
- Australian Museum (AU)
- Murdoch University (AU)
- The University of Western Australia (AU)
- Harry Perkins Institute of Medical Research (AU)
- Western Australian Museum (AU)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1021/acs.joc.5c02852
- Primary Topic
- Marine Sponges and Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 0.00