Atrial Mechanical Contraction Predicts Cerebrovascular Risk in Patients With Transthyretin Amyloid Cardiomyopathy and Sinus Rhythm
LA dysfunction, particularly AEMD and severely impaired LASc, is associated with increased cerebrovascular events in ATTR-CM. Using LAS analysis may refine risk stratification and help identify patients with ATTR-CM in SR who might potentially benefit from intensified extended rhythm monitoring or prophylactic anticoagulation.
Authors
- Beatrice Dal Passo (ORCID: https://orcid.org/0000-0002-5515-853X)
- Daniel S. Knight (ORCID: https://orcid.org/0000-0002-0512-3961)
- Josephine Mansell (ORCID: https://orcid.org/0000-0002-1778-3713)
- Lucia Venneri (ORCID: https://orcid.org/0009-0006-2551-7403)
- Ruta Virsinskaite (ORCID: https://orcid.org/0009-0009-3988-9066)
- Karola Jering (ORCID: https://orcid.org/0000-0002-5243-1959)
- Yousuf Razvi (ORCID: https://orcid.org/0000-0003-4766-3293)
- Muhammad U. Rauf (ORCID: https://orcid.org/0000-0001-8793-9333)
- William E. Moody (ORCID: https://orcid.org/0000-0002-2592-618X)
- Francesco Bandera
- T Kotecha
- Elisa Zaro
- Gaia Giampieri
- S D Solomon
- C J Whelan
- A Sheikh
- A D Wechalekar
- Alberto Aimo
- Zehra Irem Sezer
- Michele Emdin
- Raffaele De Caterina
- Aviva Petrie
- Helen Lachmann
- Aldostefano Porcari
- Ana Martinez-Naharro
- Marianna Fontana
- Philip N. Hawkins
- Julian D. Gillmore
- Clara Burgel
Institutions
- University of Pisa (IT)
- Brigham and Women's Hospital (US)
- University of Trieste (IT)
- Scuola Superiore Sant'Anna (IT)
- King's College London (GB)
- Queen Elizabeth Hospital Birmingham (GB)
- The Royal Free Hospital (GB)
- MultiMedica (IT)
- Azienda Unità Sanitaria Locale di Ferrara (IT)
- Arcispedale Sant'Anna (IT)
- Eastman Dental Hospital (GB)
- Fondazione Toscana Gabriele Monasterio (IT)
- Azienda Sanitaria Universitaria Integrata di Trieste (IT)
- University College London (GB)
Publication Details
- Journal
- Journal of the American College of Cardiology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jacc.2025.12.033
- Citations
- 1
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 22.24