Personalized mRNA vaccine induces strong, durable immunity in hard-to-treat breast cancer

In an experimental trial, a personalized mRNA vaccine was tested in 14 individuals with an aggressive form of breast cancer. It trained immune cells to target cancer-specific mutant proteins, inducing strong, lasting immunity. Ten participants remained disease-free. Analysis of relapses revealed resistance mechanisms, offering essential insights for future therapies. T cells targeting cancer-specific mutant proteins remained in treated individuals years after vaccination.

Publication Details

Journal
Nature
Published
2026-02-18
DOI
https://doi.org/10.1038/d41586-026-00477-0
Primary Topic
Immune responses and vaccinations
Type
article
Field-Weighted Citation Impact
0.00
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article

Personalized mRNA vaccine induces strong, durable immunity in hard-to-treat breast cancer

Nature
Immune responses and vaccinations
article

Personalized mRNA vaccine induces strong, durable immunity in hard-to-treat breast cancer

article en

Abstract

In an experimental trial, a personalized mRNA vaccine was tested in 14 individuals with an aggressive form of breast cancer. It trained immune cells to target cancer-specific mutant proteins, inducing strong, lasting immunity. Ten participants remained disease-free. Analysis of relapses revealed resistance mechanisms, offering essential insights for future therapies. T cells targeting cancer-specific mutant proteins remained in treated individuals years after vaccination.

Nature
Openalex Percentile: Top 49%
Immune responses and vaccinations
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Personalized mRNA vaccine induces strong, durable immunity in hard-to-treat breast cancer · Nature (2026) | TGRS Research Map | TGRS