Could vector-derived cadherin mimicry contribute to pemphigus vulgaris? An immunogenetic and in silico study involving HLA-DRB104:02 and 14:01

These findings highlight strong immunogenetic associations in PV and introduce a structurally and immunogenetically informed, hypothesis-generating Vector-derived Cadherin Mimicry (VCM) framework. By integrating genetic association data with computational modeling, this conceptual model suggests that repeated exposure to vector-derived cadherin-like proteins may represent a plausible environmental component contributing to PV susceptibility in genetically predisposed individuals. Experimental validation will be required to further evaluate this framework and its relevance to PV pathogenesis.