Decreased adipokine CTRP4 in CAD patients: CTRP4 attenuates atherosclerosis via inhibition of RAGE and TLR4
Decreased CTRP4 levels in serum and epicardial adipose tissue are associated with CAD in patients. CTRP4 deficiency promotes the development of atherosclerosis in ApoE<sup>‒/‒</sup> mice, whereas CTRP4 supplementation attenuates atherosclerosis via binding and inhibition of RAGE and TLR4. These results suggest that CTRP4 is a novel anti-inflammatory and anti-atherogenic adipokine inversely associated with CAD and a potential therapeutic target.
Authors
- Q. Chen (ORCID: https://orcid.org/0000-0002-7432-9648)
- Xinyi Shu
- J. F Liu
- Xiaowei Wu (ORCID: https://orcid.org/0000-0002-3915-5785)
- Wang Shen (ORCID: https://orcid.org/0000-0001-5779-5471)
- Feng Li (ORCID: https://orcid.org/0000-0001-5892-6496)
- R U I Y A N Zhang
- Abulikemu Amuti
- Fenghua Ding (ORCID: https://orcid.org/0000-0001-9507-4704)
- Xiaoqun Wang
- Jiawei Chen
- Leyuan Tao
- Ying Shen
- Jinwei Quan
- Lin Lu
- Yang Dai
- Shuai Chen
- Yipaerguli Maimati
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Shanghai Institute of Hematology (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/ctm2.70624
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 0.00