Alpha-1B Glycoprotein Is a Novel Hepatocyte-Derived Host Factor Associated with In Vitro Inhibition of HBV Replication and Hepatocellular Carcinoma Progression
This study provides evidence that A1BG may be a novel host factor associated with the in vitro suppression of HBV replication and HCC progression by modulating pathways related to enhanced antiviral effects, reduced proliferative capacity and stemness, and suppression of EMT. These findings suggest that A1BG is a potential therapeutic target in HBV-related HCC.
Authors
- Yosuke Murata
- Masahiro Ohtani (ORCID: https://orcid.org/0000-0003-2408-5785)
- Kazuya Takahashi (ORCID: https://orcid.org/0000-0002-5104-2601)
- Yu Akazawa (ORCID: https://orcid.org/0000-0002-8030-7373)
- Lihong Zhang (ORCID: https://orcid.org/0000-0003-1296-3237)
- Juan Lyu (ORCID: https://orcid.org/0000-0002-1366-1807)
- Takuto Nosaka
- Tatsushi Naito
- Yasunari Nakamoto
- Tomoko Tanaka
Institutions
- University of Fukui (JP)
- Shaoxing People's Hospital (CN)
Publication Details
- Journal
- Cancers
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3390/cancers18040662
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science