Microbiota-derived propionate suppresses Salmonella virulence gene expression via LuxS quorum sensing
These findings underscore the role of the gut-derived metabolite propionate in directly modulating pathogen virulence gene expression by targeting the LuxS/AI-2 quorum‑sensing system, offering novel insights into microbiota-based strategies for infectious disease management.
Authors
- Shi Shourong
- Shiyong Liao
- Qidong Zhu
- Yunqi Xiao
- Qianyun Zhang
- Shangzhou Liu
Institutions
- Poultry Research Institute (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2026-02-19
- DOI
- https://doi.org/10.1186/s40168-026-02366-0
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China