Clonal haematopoiesis of indeterminate potential and risk of incident psychiatric disorders
CHIP was associated with elevated risk of psychiatric disorders, specifically major depressive disorders and substance use disorders, with gene-specific associations observed with changes in brain WM tracts. These findings revealed a potential biological association between CHIP and psychiatric disorders, offering new insights into disease mechanisms and possible therapeutic targets.
Authors
- Jiang Li (ORCID: https://orcid.org/0000-0001-8046-8874)
- Xiao Tan (ORCID: https://orcid.org/0000-0001-6012-2761)
- Bowei Yu
- Y Sun
- Y Yu
- Y Lu
- B Wang
- Chenyi Wan
Institutions
- Uppsala University (SE)
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai Pudong New Area Gongli Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1186/s12916-026-04720-3
- Primary Topic
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00