Identification of FTO as a key m6A demethylase linking immune dysregulation to sepsis pathogenesis
FTO, identified through consensus machine learning approaches, could serve as a potential diagnostic biomarker and m<sup>6</sup>A methylation regulator for sepsis. The discovery of FTO and its downstream targets provides new insights into sepsis pathogenesis and may offer a foundation for developing novel therapeutic strategies.
Authors
- Tiantian Deng (ORCID: https://orcid.org/0009-0001-3520-0227)
- Nan Gao (ORCID: https://orcid.org/0000-0002-3903-6866)
- Yi Jiao (ORCID: https://orcid.org/0000-0001-7280-3767)
- Qishun Geng
- Cheng Xiao
- Zhaoran Wang
- G Zhang
- Weijian Zhang
- Rui Lian
- Tingting Deng
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fimmu.2026.1756059
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00