Endothelin-1/endothelin B receptor signalling mediates Prx1+ skeletal stem cells senescence: A driver of osteoporotic bone loss
This study positioned ET<sub>B</sub>R blockade as a promising novel therapeutic strategy for osteoporosis. By targeting the upstream driver of SSCs exhaustion, ET<sub>B</sub>R inhibition offers a potential paradigm shift from palliative care to proactive rejuvenation of the osteogenic niche. This approach could counteract both postmenopausal and age-related bone loss by restoring the bone-forming potential of the skeleton, addressing a significant unmet clinical need.
Authors
- Bin Tang (ORCID: https://orcid.org/0000-0001-9676-984X)
- Weiyuan Gong (ORCID: https://orcid.org/0009-0004-5357-3467)
- Chunyi Wen
- Junxin Lin
- Guozhi Xiao
- Manting Au
- Zhou Zou
- Xuan Lu
- Hongwei Ouyang
- Yuqi Zhang
Institutions
- Hong Kong Polytechnic University (HK)
- Southern University of Science and Technology (CN)
- Zhejiang University-University of Edinburgh Institute (CN)
- Zhejiang University (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2026-02-18
- DOI
- https://doi.org/10.1016/j.jot.2026.101048
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00