Quantitative evaluation of iron chelator effects on central motor and sensory tracts in superficial siderosis
TMS and SEP are sensitive tools for evaluating central conduction impairment in SS. The conduction abnormality, likely caused by a different pathomechanism from that in MS, is partially recoverable by iron chelator administration. CMCT improvement demonstrates partial reversibility of impaired motor pathway and supports the therapeutic potential of iron chelator therapy in SS.
Authors
- Miho Akaza
- Tadashi Kanouchi
- Motonori Hashimoto
- Yurie Nose
- Satoru Egawa (ORCID: https://orcid.org/0000-0001-9367-3906)
- Ryo Iwase (ORCID: https://orcid.org/0000-0002-8115-7223)
- Nobuo Sanjo
- Toshitaka Yoshii
- Takanori Yokota
Institutions
- Tokyo Medical and Dental University (JP)
- Tokyo University of Science (JP)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-02-18
- DOI
- https://doi.org/10.3389/fneur.2026.1734951
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00