Prussian blue nanozymes alleviate postoperative pain via upregulating endogenous SMOC2 secretion in dorsal root ganglion fibroblasts

This work establishes an "endogenous analgesia" strategy in which PBzymes alleviate postoperative mechanical pain by upregulating fibroblast-derived SMOC2 in the DRG. Evidence from loss-of-function, gain-of-function, and functional electrophysiological studies supports a central role for SMOC2 in this mechanism. The approach presents a promising, sustained, non-opioid avenue for pain management.